Overexpression of TRPM7 is Associated with a Poor Prognosis in Human Ovarian Carcinoma

Ovarian cancer is one of the most common cancer in women and it is the leading cause of death in gynaecological cancer (Siegel et al., 2013). In China, the age-adjusted incidence and motility rate of ovarian cancer is 5.35 and 1.6 per 100,000, respectively (Kim et al., 2009; Wang et al., 2014). Although substantial advances in surgical techniques and chemotherapeutic treatments have been made in ovarian cancer, only approximately 30% patients with ovarian cancer can survive 5 years after the initial diagnosis (Vaughan et al., 2011). The poor ratio of survival is primarily attribute to lacking of specific symptoms and effective methods for the early detection in ovarian cancer patients (Vaughan et al., 2011). In addition, the development of multidrug resistances also leads to the failure in treatment of ovarian cancer (Thigpen et al., 2011; Pitakkarnkul et al., 2013). Thus, identification of molecular markers for prognosis is important for improving therapeutic methods and extending survival of ovarian cancer patients. The transient receptor potential (TRP) channels play a key role in maintaining cellular calcium homeostasis (Ramsey et al., 2006). They are also reported to express in cancer cells and be involved in tumor development